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KMID : 0606920200280020131
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Biomolecules & Therapeutics
2020 Volume.28 No. 2 p.131 ~ p.136
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Spinosin Attenuates Alzheimer’s Disease-Associated Synaptic Dysfunction via Regulation of Plasmin Activity
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Cai Mudan
Jung In-Ho
Kwon Hui-Young
Cho Eun-Bi
Jeon Ji-Eun
Yun Jean-Ho
Lee Young-Choon
Kim Dong-Hyun
Ryu Jong-Hoon
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Abstract
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Hippocampal synaptic dysfunction is a hallmark of Alzheimer’s disease (AD). Many agents regulating hippocampal synaptic plasticity show an ameliorative effect on AD pathology, making them potential candidates for AD therapy. In the present study, we investigated spinosin as a regulating agent of synaptic plasticity in AD. Spinosin attenuated amyloid β (Aβ)-induced long-term potentiation (LTP) impairment, and improved plasmin activity and protein level in the hippocampi of 5XFAD mice, a transgenic AD mouse model. Moreover, the effect of spinosin on hippocampal LTP in 5XFAD mice was prevented by 6-aminocaproic acid, a plasmin inhibitor. These results suggest that spinosin improves synaptic function in the AD hippocampus by regulating plasmin activity.
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KEYWORD
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Spinosin, Alzheimer’s disease, Plasmin, LTP, 5XFAD
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